Computational mouse atlases and their application to automatic assessment of craniofacial dysmorphology caused by the Crouzon mutation Fgfr2C342Y

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چکیده

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Sparse Statistical Deformation Model for the Analysis of Craniofacial Malformations in the Crouzon Mouse

Crouzon syndrome is characterised by the premature fusion of cranial sutures. Recently the first genetic Crouzon mouse model was generated. In this study, Micro CT skull scannings of wild-type mice and Crouzon mice were investigated. Using nonrigid registration, a wild-type craniofacial mouse atlas was built. The atlas was registered to all mice providing parameters controlling the deformations...

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ژورنال

عنوان ژورنال: Journal of Anatomy

سال: 2007

ISSN: 0021-8782,1469-7580

DOI: 10.1111/j.1469-7580.2007.00751.x